The 25th Canadian Connective Tissue Conference
Wednesday May 29-Friday May 31, 2019
SCIENTIFIC PROGRAM
| Day 1 | Wednesday May 29, 2019 Thomson House McGill Campus 36 50 McTavish Street Montréal, QC H3A 1X9 |
| 19:00 h | Registration Opens |
| 19:00 – 21:30 h | Welcome Reception, Thomson House, McGill Campus |
| Day 2 | Thursday May 30, 2019 Shriners Hospital for Children—Canada 2nd floor Conference room |
| 7:45 – 8:30 h |
Breakfast |
| 8:30 – 8:45 h |
Welcome Remarks |
| SESSION I: | Connective tissue development in health and disease Co-chairs: Morris Manolson and Annie Levasseur |
| 8:45 – 9:15 h |
Keynote speaker: René St-Arnaud – Shriners Hospital for Children—Canada 24,25-dihydroxyvitamin D and fracture repair: from mechanisms to clinical trial |
| 9:15 – 10:05 h |
Selected abstracts for oral presentation |
| 9:15 – 9:25 h |
Rongmo Zhang – McGill University Involvement of microRNAs in aortic aneurysm formation in Marfan syndrome |
| 9:25 – 9:35 h |
Byron Chan – University of Toronto The actin binding protein adseverin is involved in regulating articular chondrocyte phenotype |
| 9:35 – 9:45 h |
Elizabeth Zimmermann – Shriners Hospital for Children—Canada Examining tissue composition, whole-bone morphology and mechanical behavior in Marfan Syndrome |
| 9:45 – 9:55 h |
K.J. Aitken – Hospital for sickkids Toronto AKT pathway in bladder obstruction and matrix-induced smooth muscle phenotype |
| 9:55 – 10:05 h |
Omar Al Rifai – Institut de Recherches Cliniques de Montréal Regulation of FGF23 processing and bone mass accrual by the proprotein convertase furin |
| 10:05 – 10:30 h |
Invited speaker: Colin Crist – Lady Davis Institute Translational control of skeletal muscle stem cell quiescence and self-renewal |
| 10:30 – 10:45 h |
Coffee break |
| SESSION II: | Genetics and molecular biology of connective tissue disorders Co-chairs: Dieter Reinhardt and Joanne Tang |
| 10:45 – 11:10 h |
Invited speaker: Luda Diatchenko – McGill University Understanding chronic pain through genomics and transcriptomics |
| 11:10 – 11:50 h |
Selected abstracts for oral presentation |
| 11:10 – 11:20 h |
Hélène Mathieu – Centre de recherche du CHU Sainte Justine Genetic analysis of familial AIS: Implication of ciliary genes |
| 11:20 – 11:30 h |
Gilles Tremblay – Forbius (Formation Biologics) Development of AVID200, a novel TGF-beta 1 & 3 inhibitor for the treatment of fibrotic diseases |
| 11:30 – 11:40 h |
Elizabeth Stephens – University of Sherbrooke Dysregulated microRNA expression in osteoclasts from Paget’s disease of bone |
| 11:40 – 11:50 h | Mariya Stavnichuk – McGill University Progressive bone gain in G6b-B knock-out mice |
| 11:50 – 12:15 h | Invited speaker: Philippe Campeau – The Centre Hospitalier Universitaire Sainte-Justine Understanding growth plate disorders to better treat them |
| 12:15 – 13:45 h | Lunch and Poster presentation Session 1 CCTS Board Meeting (board members only) |
| SESSION III: | Connective tissue repair and regeneration Co-chairs: Lisbet Haglund and Kyle MacDonald |
| 13:45 – 14:10 h | Invited speaker: Roman Krawetz – University of Calgary The role of cell cycle activation in endogenous cartilage regeneration |
| 14:10 – 15:00 h | Selected abstracts for oral presentation |
| 14:10 – 14:20 h | Rayan Fairag – McGill Univesity Feasibility of 3D-printed polylactic acid (PLA) scaffolds in promoting bone-like matrix deposition in vitro |
| 14:20 – 14:30 h | Marianne Comeau-Gauthier – Research Institute MUCH Montreal Accelerating fracture repair by activating Wnt/β-catenin signaling pathway via Tideglusib release |
| 14:30 – 14:40 h | Nan Wu – University of Toronto YAP circular RNA, circYAP, attenuates cardiac fibrosis via binding with tropomyosin-4 and gammaactin |
| 14:40 – 14:50 h | Elie Akoury – McGill University Low-dose zoledronate for local delivery to patient-derived spinal bone metastasis secondary to lung cancer |
| 14:50 – 15:00 h | Sarah Hedtrich – University of British Columbia Myofibroblast reprogramming in hypertrophic scars is mediated by adipocytes via BMPs |
| 15:00 – 15:25 h | Invited speaker: Julie Fradette – Laval University Engineering natural organ specific 3D models for in vitro and pre-clinical studies |
| 15:25 – 15:40 h | Coffee Break |
| 15:40 – 16:10 h | CCTS Business Meeting/General Assembly (all CCTC participants) |
| SESSION IV: | Short communications Co-chairs: Craig Simmons and Rosalie Fortin-Trahan |
| 16:10 – 16:20 h | Industrial talk Cellink Bioprinting: Materials, methods and motivations |
| 16:20 – 17:00 h | Selected abstracts for short oral presentations |
| Daniel Bisson – McGill University Role of Toll-like receptors in degenerating scoliotic facet joints Poulami Datta – Krembil Research Institute Iris Boraschi-Diaz – Shriners Hospital for Children – Canada Chrisanne D’souza – McGill University Salem Werdyani – Memorial University of Newfoundland Alice Bouchard – Shriners Hospital for Children—Canada Magdalena Wojtas – University of Toronto Fei Geng – McMaster University Hana Hakami – McGill University Patrick Murphy – University of Western Ontario |
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| 18:30 – 22:00 h | Gala Dinner and Social event McGill University Faculty Club, McGill Campus 3450 McTavish Street Montréal, QC, H3A 0E5 |
| Day 3 | Friday May 31, 2019 Shriners Hospital for Children—Canada 2nd floor Conference room |
| 7:45 – 8:30 h | Breakfast |
| SESSION V: | Fundamentals of extracellular matrix biology Co-chairs: Mari Kaartinen and Brian Wu |
| 8:30 – 8:55 h | Invited speaker: Sylvie Ricard-Blum – University Lyon Insights into the structure, interactions and functions of a matricryptin, the pro-peptide of lysyl oxidase |
| 8:55 – 9:45 h | Selected abstracts for oral presentation |
| 8:55 – 9:05 h | Nina Noskovicova – University of Toronto Inhibiting fibrotic encapsulation of body implants by targeting mechanical activation of profibrotic TGF-β1 |
| 9:05 – 9:15 h | Venket Ravivarma – Western University Cytokines enhance interactions between TßL1, TßLR1, Small Ubiquitin-like MOdifiers (SUMOs) and ß-catenin in palmar fascia fibroblasts |
| 9:15 – 9:25 h | Helal Endisha – Krembil Research Institute, University Health Network Elucidating the functional role of miR-34a in osteoarthritis pathogenesis – Involvement in obesity and osteoarthritis |
| 9:25 – 9:35 h | Nuno Coelho – University of Toronto Myosin phosphatase Rho-interacting protein regulates DDR1-myosin II interactions and collagen contraction |
| 9:35 – 9:45 h | Ahmed Alshaer – McGill University Free calcium regulates the expression of proteoglycan and collagen in human cartilage |
| 9:45 – 10:10 h | Invited speaker: Kjetil Ask – McMaster University Cellular and molecular phenotyping and imaging pipeline for target characterization in archived biobank samples |
| 10:10 – 10:25 h | Coffee Break |
| SESSION VI: | Clinical and translational research in connective tissue biology Co-chars: Sophie Roux and Pouyan Ahangar |
| 10:25 – 10:50 h | Invited speaker: Edward Harvey – McGill University Taking Temperature Modulation from the Bedside to the Bench |
| 10:50 – 11:30 h | Selected abstracts for oral presentation |
| 10:50 – 11:00 h | Leah Ferrie – University of Calgary The role of exogenous and endogenous stem cells and biomaterials in bone fracture healing |
| 11:00 – 11:10 h | Jose Ramirez-Garcialuna – McGill University Enhanced bone repair after fracture priming |
| 11:10 – 11:20 h | Myron R. Szewczuk – Queen’s University Aberrant sialoglycan patterns facilitate 3D multicellular spheroid and xenograft tumor formation |
| 11:20 – 11:30 h | Hosni Cherif – McGill University Natural senolytics to relief back pain |
| 11:30 – 11:55 h | Invited speaker: Saija Kontulainen – University of Saskatchewan Strong bones across the lifespan: role of mechanical loading |
| 12:00 – 13:30 h | Lunch and Poster presentation Session 2 |
| SESSION VII: | Imaging, genetics and high-throughput screening of connective tissues Co-chairs: Fackson Mwale and Alexandria DeCarlo |
| 13:30 – 13:55 h | Invited speaker: David Holdsworth – Western University Pre-clinical and clinical imaging of the musculoskeletal system |
| 13:55 – 14:35 h | Selected abstracts for oral presentation |
| 13:55 – 14:05 h | Amanda Ali – Krembil Research Institute Known and novel circulating microRNAs are uniquely expressed in knee osteoarthritis |
| 14:05 – 14:15 h | Annie Levasseur – École de technologie supérieure Can micro-computed tomograhy detect bone adaptations from ex vivo culture? |
| 14:15 – 14:25 h | Hadla Hariri – Shriners Hospital for Children—Canada Usp53, a PTH target regulating bone turnover and mesenchymal stem cell differentiation |
| 14:25 – 14:35 h | Joanne Tang – Western University The non-invasive modelling of body-wide inflammation in Duchenne muscular dystrophy |
| 14:35 – 15:00 h | Invited speaker: Lidan You – University of Toronto Bone cell crosstalk under mechanical loading |
| 15:00 – 15:30 h | Awards Presentation & Concluding Remarks |