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Program 2017

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THURSDAY, May 18

6:00- 9:00pm Registration, Reception and Refreshments

 

FRIDAY, MAY 19

7:45 – 8:30am Light Breakfast
7:45 – 3:00pm Registration Desk Open
8:30 – 8:45am Welcome Remarks from Co-Chairs of Organizing Committee.

Anie Philip, McGill University

Stephane Roy, Université de Montréal

 

SESSION I – BONE AND CARTILAGE DISEASE: MECHANISTIC AND REGULATORY ASPECTS

Moderators: Lauren Flynn and Jean Vacher

 

8:45 – 9:30am Keynote Lecture: “Influence of Surface Topography and Micromotion on Healing at the Bone-Implant Interface.”

Antonio Nanci, Université de Montréal, Montreal, QC

 

9:30 – 10:30am Selected Abstracts

9:30am “MicroRNA-34a: Role In The Development Of Osteoarthritis During Obesity.”

Helal Endisha, University of Toronto, ON.

9:40am “Cartilage-Specific ULK-1 Knockout Induces Inhibition Of Autophagy Pathway And Increased Cartilage Destruction With Secondary Inflammatory Effects On Synovium.”

Brain Wu, Krembil Research Institute, University Health Network, Toronto, ON.

9:50am “High-Fat Diet-Induced Acceleration Of Osteoarthritis Is Associated With Sustained Metabolite Signature Regulated By Leptin/Autotaxin Pathway.”

Poulami Datta, University of Toronto, ON.

10:00am “Modulation of Parathyroid Hormone Receptor 1 Signaling By Extracellular Nucleotides.”

Brandon H. Kim, Schulich School of Medicine & Dentistry, Western University ON.

10:10am “Role of Osteoblast Menin In Bone Metabolism: In-Vivo Studies Of Knockout Mice.”

Jad Abi-Rafeh, Division of Experimental Medicine, McGill University, Montreal, ON.

10:20am “Mechanically-Evoked ATP Release Is Regulated By Facilitated Membrane Resealing In Murine Osteoblasts.”

Nicholas Mikolajewicz, Shriners Hospital for Children, McGill University

 

10:30 – 10:45am Coffee and Networking Break

 

SESSION II – CONNECTIVE TISSUE DISEASE CHARACTERISTICS: CLINICAL AND FUNDAMENTAL ASPECTS

Moderators: Fackson Mwale and David O’Gorman

 

10:45 – 11:15am Invited Talk: “Elucidating the Role of POC5 in Idiopathic Scoliosis.”

Florina Moldovan, Université de Montréal, CHU Sainte-Justine Research Center, Montreal, QC

 

11:15- 12:15pm Selected Abstracts

11:15am “Characterizing Degeneration Of Facet Joint Cartilage In Adolescent Idiopathic Scoliosis.”

Daniel Bisson, McGill University & Shriner’s Hospital for Children, Montreal, QC.

11:25am “Effect Of Tissue-Specific Extracellular Matrix On The Adipogenic And Chondrogenic Differentiation Of Human Adipose-Derived Stromal Cells.”

Danielle Heinbuch, University of Western Ontario, London, ON.

11:35am “Characterization Of Proteins In The Specialized Basal Lamina Associated With The Tooth.”

Aurélien Fouillen, Université de Montréal, Montréal, QC.

11:45am “Use Of Unfixed Histology To Visualize And Characterize Meniscus Inter-Tie Coil Structures In Intact Knees And Knees Following Surgical Procedures.”

Colleen Mathieu, Ecole Polytechnique de Montreal, Montreal, QC.

11:55am “Role Of Phex-Fgf23 Axis And Γ-Carboxylation On Vascular Calcification Caused By Mgp Deficiency.”

Abhinav Parashar, McGill University, Montréal, QC.

12:05pm “Male Mice Are More Susceptible To Whole-Body Vibration Induced Joint Damage Than Age-Matched Female Mice.”

Geoffrey Kerr, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON.

 

12:15 – 2:00pm LUNCH/ Poster Viewing

 

12:15 – 2:00pm CCTS BOARD MEETING

 

SESSION III – BONE AND CARTILAGE: GENETIC AND DEVELOPMENTAL ASPECTS

Moderators: Svetlana Komarova and Showan N Nazhat

 

2:00 – 2:30pm Invited Talk: “Building articular cartilage: A new blueprint.”

Rebekah S. Decker, Genomics Institute of the Novartis Research Foundation

 

2:30 – 3:00pm Selected Abstracts

2:30pm “Identifying Gli Transcriptional Targets In Chondrosarcoma Using Next Generation Sequencing.”

Amanda Ali, University Health Network, Toronto, ON.

2:40pm “Undercarboxylated Osteocalcin And Metabolic Phenotype In The Mouse Model Of Osteogenesis Imperfecta.”

Iris Boraschi-Diaz, Shriners Hospital for Children, McGill University, Montreal, QC.

2:50pm “Biological Repair Of Osteoarthritic Cartilage Using Short Link N.”

Muhammad Albesher, Lady Davis Institute for Medical Research, McGill University, Montreal, QC.

 

3:00 – 3:15pm Coffee and Networking Break

 

SESSION IV – Selected Abstracts

Moderators: Rebekah S. Decker and Morris Manolson

 

CONNECTIVE TISSUE REPAIR AND FIBROSIS: CELLULAR AND MOLECULAR ASPECTS

3:15pm “Toll-Like Receptor Activation Induces Human Intervertebral Disc Degeneration.”

Emerson Krock, McGill University, Montreal, QC.

3:25pm “Investigating The Role Of Pannexin 3 As A Regulator Of Intervertebral Disc Health.”

Meaghan E. Serjeant, Schulich School of Medicine and Dentistry, Bone and Joint Institute, University of Western Ontario.

3:35pm “Functional relevance of Fibulin-4 interactions with latent transforming growth factor beta binding protein- 4 in the context of fibronectin and fibrillin-1.”

Heena Kumra, McGill University, Montreal, QC.

 

BONE AND CARTILAGE DISEASE: TRANSLATIONAL AND CLINICAL ASPECTS

3:45pm “Synovial Membrane Nerve Fiber Density Decreases With Osteoarthritis In Horses.”

Raymond Pujol, University of Montreal, St. Hyacinthe, QC.

3:55pm “Lactosylceramide Enhances Chondrocytic Differentiation.”

Lilit Antonyan, Research Centre, Shriners Hospitals for Children, McGill University, Montreal, QC.

4:05pm “Novel Electromechanical Arthroscopic Device For The Objective And Quantitative Evaluation Of Cartilage Quality.”

Insaf Hadjab, Institute of Biomedical Engineering, Polytechnique Montreal, Biomomentum Inc.

4:15 – 5:45pm Poster Presentations and Viewing

 

6:00pm – 9:00pm Reception and Formal Dinner (Ticketed Event)

McGill La Citadel 26th Floor Lounge, 410 Sherbrooke St W, Montreal, QC. H3A 1B3

Keynote Talk: “Mechanistic Modeling: The Pathway to Precision Medicine”

V. A. Shiva Ayyadurai, Chairman and CEO, CytoSolve, Inc.

 

SATURDAY, MAY 20

8:00 – 9:00am Light Breakfast
8:30 -10:30am Registration Desk Open
8:30 -9:00am CCTS BUSINESS MEETING/GENERAL ASSEMBLY

 

SESSION V – TISSUES REPAIR, REPLACE OR RE-ENGINEER

Moderators: Rene Harrison and Julie Fradette

 

9:00 – 9:45am Keynote Talk: “Connective Tissue Signaling Through Cell Adhesions in Matrix Homeostasis and Fibrosis.”

Christopher A. McCulloch, University of Toronto, Toronto, ON

 

9:45 – 10:15am Selected Abstracts

9:45am “Naturally Derived Microcarriers As Tissue-Specific 3-D Cell Culture Platforms.”

Anna Kornmuller, Western University.

9:55am “T1ρ Mri Detection And Histological Evaluation Of Autologous Nucleus Pulposus Cell-Seeded Hydrogel Delivery To Isolated Human Intervertebral Discs In Dynamic Culture.”

Derek H. Rosenzweig, McGill University, Montreal, QC.

10:05am “Blood And Lymphatic Microvascularization Of Self-Assembled Skin Substitutes Using Primary Human Endothelial Cells.”

Jennifer Bourland, Centre de recherche en organogenese expérimentale de l’Universite Laval / LOEX, Quebec, QC.

10:15 – 10:30am Coffee and Networking Break

 

10:30 – 11:00am Invited Talk: “Osteogenesis Imperfecta – What causes it? What to do about it?”

Frank Rauch, McGill University, Shriners Hospital for Children, Montreal, QC

 

11:00 – 11:30am Selected Abstracts

11:00am “Chiral Switching Of Calcium Carbonate Biomineral Induced By A Single Chiral Enantiomer Of Amino Acid.”

Wenge Jiang, McGill University, Montreal, QC.

11:10am “An Injectable Chitosan Scaffold With Mechanical Properties Optimized For IVD Repair.”

Yasaman Alinejad, École de technologie supérieure (ETS), Montréal, QC.

11:20am “Regulation Of Matrix Gla Protein Gene Expression By An Intronic Sequence.”

Jobran Mohammed Moshi, McGill University, Montreal, QC.

 

11:30 – 12:15pm Invited Talk: “Nuclear receptors in cartilage and osteoarthritis.”

Frank Beier, Western University, London, ON

 

12:15 – 12:45pm Awards Presentation and Concluding Remarks

 

12:45 – 2:30pm Lunch and Poster Breakdown

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